... Cl HHH o H CH3 CH3 CH CI HHH o H OCH3 OCH3 N Cl HHH o H CH3 OCH3 N a HHH o H CH3 CH3 N a HHH o H OCH2CH3 och2ch3 N Cl HHH o H NHCH3 OCH2CH3 N Cl HHH o ...

... lH-imidazol-2-yl Cl HHH NR8 Cyclopentylcarbonyl- — lH-imidazol-2-yl Cl HHH ... 5-Phenyl- Cl HHH [l,3,4]thiadiazol- 2-yl O — — lH-imidazol-2yl Cl HHH o ...

DV TABLE 1 Compound No ABDE vx Y R1 R1 G 1 H Br HHH 0 O CH; H OC2H5 3 H Cl HHH 0 0 HH OCZH; 11 HHHHH 0 0 HH oczH; 12 HHHHH oo CH; H OC;H; 13 H Cl HHH oo CH; ...

CF3 HHHO OCH3 OCH3 CH CF3 HHHO OCH3 CH3 CH CF3 HHHO CH3 CH3 CH CF3 HHHO OCH3 ... OCH3 CH FHHHO OCH3 OCH3 CH -h HHHO OCH3 OCH3 CH Cl HHHO OCH3 OCH3 CH Cl ...

77 + NO CH CF3 HHH 79 + NO CH Cl HHH 81 + N o CH Cl HHH 83 + N o CH Cl HHH 85 + N o CH CF3 HHH 87 + ONN Cl HHH 89 + N o CH CF3 HHH 91 + N o CH Me HHH 93 + N ...

9 R8 x Y zmpw) R Rg R9 R10 O. X1m.p.(°C.) s-sCF;H a-CH; H OCH; OCH; CH s-CO;CH; z-CH; ... HHH CH; OCH; ll 6-Cl HHH CH; OCH; S02NHCN-< 0 6-CH3 HHH CH; OCH; ...

... F CI HHH OH 1-63 F CI HHH OCH3 1-64 F CI HHH OC2H5 1-65 F CI HHH OCH(CH3)2 ... CI Cl HHH OH 1-144 CI Cl HHH OCH3 1-145 CI Cl HHH OC2H5 1-146 CI Cl HHH ...

19 TABLE 3-continued 25 Cl 30 35 40 45 50 55 60 65 20 TABLE 3-continued Cl ... 0 0 cyHj Cl Cl H CH3 HH 0 o i-C3H7 Cl Cl HH CH3 H 0 0 i-C3H7 Cl Cl HHH CH3 0 ...