United Slates Patent im Cronin et al. [in 3872171 [45] Mar. 18, 1975 [54] POLY AMINES AS ANTIVIRAL AGENTS IN ANIMALS [75] Inventors: Timothy H. Cronin, ...

US005258039A United States Patent [19] [ii] Patent Number: 5258039 Goh et al. ... Inventors: James CH Goh; SL Toh; TE Tay, all of Singapore, Singapore [73] ...

H OH O— CH3 O— C2H5 0-n-CiH7 CM-C3H7 O-11-C3H7 CM-C4H9 OS-C4H9 CM-C4H9 O— (CH2)2 — CI O— CH2— S— CH3 O— CH2— Ph O— Ph O— CH2— CH=CH2 O— CH2— C=CH O— CH2— O— ...

N. or H3C T if n is 4, Xis [0016] CH3, and, CH3 CH2 -CH2 C — CH2' CH2 ( pentaerythrityl), -CH2— CH — CH — CH2- -CH2 CH2 — CH — CH — CHv -CH2 CH2— CH — CH ...

15 16 TABLE A-2-continued Rl R1 (1) (CH3) O—R-fi—N/ XO Yn (CH3)m 58 C1 1 C1 0 CH (CH3) H 3'-CH3 132—l33.5 59 Cl l Cl 0 CI-l(CH3) H 3'-CF; 1ZS—126 61 Cl 1 Cl ...

00 (m, 2H, :CH+CHH), 5.49 (s, 1H, CHH), 5.31-5.34 (m, 1H, CHO), 3.17 (br s, 1H, CH), 2.85 (br s, 1H, CH), 2.13-2.19 (m, 1H, CHH), 1.88 (s, 3H, CH3), ...

US 7964277 B2 Goh et al. (45) Date of Patent: *Jun. ... ent, or zrm — oate a tewart 74 A ey Ag F' Ch H ll&S LLP (56) References Cited US PATENT DOCUMENTS ...

-continued o Vv - CH2CH=CH(CH2)3COOR3 (T) deprotection ... (T) deprotection (2) optional esterification and/or salification CH2CH=CH(CH2)3COOR1 ...