35 EXAMPLE 2 Test substance was administered (30 or 100 mg/kg) to groups of 5 ... IP 20 ml/kg 4 6.3 5.7 0 X 6.5 5.7 SEM 0.2 0.2 Compound I IP 30 mg/kg 1 6.4 ...

EXAMPLE 2 [0302] Test substance was administered (30 or 100 mg/kg) to groups ... IP 20 ml/kg 4 6.3 5.7 0 X 6.5 5.7 SEM 0.2 0.2 Compound I IP 30 mg/kg 1 6.4 ...

EXAMPLE 4 [0308] Test substance was administered PO (30 mg/kg) to a group of ... I IP 30 mg/kg 1 6.4 5.8 0 Compound I IP 30 mg/kg 2 7.3 5.0 Compound I IP 30 ...

... 0.294 0.273 0.253 M40403 ip 30 mg/kg qd day - 1 to 3 Control v 0.985 0.231 0.985 0.746 0.013 0.297 0.865 0.459 0.047 0.610 0.283 0.012 M40403 ip 3 mg/kg ...

ip (30 mg/kg) 41.6 po (30 mg/kg) — ip (30 mg/kg) 51.2 po (30 mg/kg) — ip (30 mg/ kg) 30.5 po (30 mg/kg) 25.6 ip (30 mg/kg) 30.6 po (30 mg/kg) 38.1 ip (30 ...

[0086] Camosic acid was evaluated at 1 0, 20 and 30 mg/kg (ip, 30 min prior to the test) and at 200 mg/kg (po, 24, 5 and 1 h prior to the test) and was ...

Risperidone (0.2 mg/kg) was prepared in distilled water and injected ip 30 minutes prior to testing. All drugs were administered in a volume of 1 ml/kg.

In summary, unlike morphine at 8 mg/kg ip, 4H-thieno[3,2-b]pyrrole- 5-carboxylic acid at either 10 or 30 mg/kg ip did not significantly reduce the number of ...