R3 R4 R1 R2 R3 R4 R5 W z Y1 Y2 Y3 15 R1 R2 R3 R4 R5 W z Y1 Y2 Y3 4-8 HHHH Me CO HH Me H 4- ■70 H Br HH Me CO HHHH 4-9 HHHH Me CO HHH Me 4- ■71 HH Br H Me ...

... HH CF3CH2CO HH cyclo-PrCH2CO HH MeCOCH2CO HH cyclo-PrNHCO HH CHCCH2NHCO HH CH2=CHCH2NHCOH H MeCO HH EtCO HH CF3CH2CO HH MeCO HH EtCO HH cyclo-PrCO HH ...

TABLE 1A The following abbreviations are used in Table 1A: Me — methyl; ... Me CN H 17 iBu $CO iPr CN H 18 4> $CO 4- CN H hydroxy- butyl 19 2-(S- $CO Me HH ...

(X)IR R1 R2 R4 R3 A n 7-54 3,5-diCl CF3 HH N-Me-tetrazoinone CH 1 7-55 3,5-diCl ... MeCO H CH 1 7-64 3,5-diCl CF3 HH MeCO NH2 CH 1 7-65 3,5-diCl CF3 HH MeCO ...

R3b R3c RM R3e n R2' R2" Ra Rb Rc 363 CO FHHFH 1 Me Me HHH 364 CO CI CI HHH ... HHH Me Me 382 CO HHH Me H 1 HH Me H Me 383 CO H CF3 HHH 1 HH Me H Me 385 CO ...

... 252 H Me CO- -Me Me CF3 H 253 H Me CO- -Me Et H 4-N02 254 H Me CO- -Me Pr ... CI 2-C1 301 Et HHH CF3 H 302 Et HH Me H 2-N02 303 Et HH Et CF3 H 304 Et HH ...

R1 R2 R3 R« R5 W n 1-9 Me HH HO Me CH2 1 1-10 Me HH HO Me CH2 2 1-11 Me HH HOOCCH20 Me CH2 1-12 Me HH HOOCCH2O Me CO 1-13 Me HH AcO Me CH2 1-14 Me HH AcO Me ...

Ri R2 R3 Ra Rb R 1.98 HHH 4-F-Ph HH 1.99 HHH 4-Cl-Ph HH 1.100 HHH 4-Cl-Ph ... 1.108 5-Me HH 3,4-di-OH- HH (HC1) PH 1.109 2,4,6-tri-iP- HH Ph HH Ph-CO- 1.110 ...