... R3 ZXYW 11-124 COOH Phenyl 3-HOOCCH2-4-Cl-PhenylCO-HN— CH2— HH Me Me CH NNO ... CNNO 11-129 COOH Phenyl (N-MeCO-N-(4-OMe-3-Me-Phenyl))-N— CH2— HH Me Me ...

... phenyl- Me(CO)0— t-Bu(CO)0- Et(CO)0— HH 2-F3CO- Me(CO)0- phenyl- HH 2,6-di- Et- Me(CO)0— 4-Me- phenyl- HH 2,6-di-Cl- Me(CO)0— phenyl- HH 2,6-di-Cl- ...

... CO 341 Ph Me S02Ph HH CO 418 Ph Me N02 HH CO 342 Ph Me S02Ph H Me CO 419 Ph ... CO 35 375 Ph Me S02Me H 2-C1— Ph CO 450 Ph Me 3-OS02Me Phenyl 376 Ph Me ...

Compound 1, a preferred compound where Rt is phenyl, R2 is benzoyl, and R3, ... CN H 17 iBu $CO iPr CN H 18 4> $CO 4- CN H hydroxy- butyl 19 2-(S- $CO Me HH ...

... HH, H CO 571.5 572 27 121 H 3,4-(OCHJPh H 3-N02-phenyl H, HH, H CO 480.5 481 10 122 H 3,4-(OCH2)Ph H 3-N02-4-Me-phenyl H, HH, H CO 494.5 495 33 123 H 3 ...

F3C- (CO)O — phenyl- A5 HH 2-C1-6- t-Bu- 1.17 (s,9H), 2.27 (d, 3H), 3.87 (s,3H), 7.19 (m, 2Ff), 8.49 (d, 1H), 8.58 (d, 1H). F-5-Me- (CO)O— phenyl- A6 HH ...

... Me H Me H 251 6.10' 1.11 L1 ccc H Br HHH 301/303 5.90' 1.12 L1 ccc HH NH, HH ... 6.66' 1.22 L1 ccc co,lvle H OH HH 297 4.71' 1.23 L1 cccc(o)NH, H Me HH ...

X1 — Y' CO,H TABLE 6 TABLE 7 R1 R2 R3 (position of substitution) R4 R5 A X1 Z ... (7) Me Me HH Me Me OHHS Me Me S Me HS Me Et O NHCO CONH Bond Bond CO Bond ...